CogSpan™ 6-Month Immersive
Your brain built
everything you have.
Isn't it time
someone looked after it?
CogSpan™ — the measure of your brain's healthy life — is the only metric that truly matters. Living Method offers a physician-designed, patent-pending 6-month immersive protocol that goes beyond guesswork.
Through advanced diagnostics, we identify the precise drivers of brain and body aging and craft a personalized Blueprint to address them at the root.

A precision 3-step framework that measures your CogSpan™ — the total span of time your brain remains clear, sharp, functional, and independent — identifies your accelerators, and deploys a personalized optimization protocol. Then proves it worked.
SOUND FAMILIAR?
Many high-performers are
losing their cognitive edge — silently.
Over the past decade, reports of serious difficulty concentrating, remembering, and making decisions have risen 40% in U.S. adults — and nearly doubled in people under 40. These aren't sick patients. Many are doing "everything right." And still they're falling behind.
1pm
The Wall
The energy crash that didn't used to happen. You used to power through. Now you're barely managing around it.
↓
Lost Edge
You're keeping up in meetings. You used to be three moves ahead. The gap between you and your best is widening.
½ sec
Slower Recall
Names take just a half-second longer than they should. You catch yourself searching for words that used to come instantly.
0
Nothing Left
Your family is right there — and you have nothing left to give them. Cognitive fatigue doesn't clock out at 5pm.
"I kept thinking I was just tired, stressed, or getting older because my labs are always normal. But the CogSpan Immersive Program quickly uncovered several concerning issues. This is the first time I've felt like someone is really looking at my health."
COGSPAN IMMERSIVE MEMBER, AGE 52
THE SCIENCE IS CLEAR
The 10–25 Year Window.
The silent gap no one talks about.
Dementia starts decades before symptoms appear. By the time a diagnosis is made, up to 40% of neurons may already be lost. The window to act is now.
Age 45–50
SILENT ONSET
Amyloid plaques and neuroinflammation begin to accumulate. No symptoms. Normal labs. This stage is always missed.
Age 50–60
THE CRITICAL WINDOW
Cognitive edge erodes: slower recall, word-finding difficulty, mental fatigue. Conventional medicine has no reason to act.
Age 60–75
PREVENTION WINDOW SHORTENS
Brain volume loss becomes measurable on MRI. Mild cognitive impairment may be clinically diagnosed.
Age 70+
DIAGNOSIS
By the time dementia is diagnosed, 40% of neurons may already be lost. The time to act was decades earlier.
40%
of neurons may already be lost by the time dementia is diagnosed. Your labs came back normal. Your doctor sees nothing wrong. But "normal" on standard labs doesn't mean your brain is aging optimally. CogSpan was built specifically to find what conventional medicine misses — in the years when it still matters.
BUILT FOR HIGH-PERFORMERS
We watch over your brain
so you can build your legacy.
We built a program for people who refuse to accept decline — who want root-cause data, not symptom management.
The Executive
Leads high-stakes decisions and notices the first signs of cognitive fatigue after 5pm.
The Physician
Knows the science. Wants root-cause data, not symptom management and pills.
The Entrepreneur
Performance is a competitive advantage. Can't afford cognitive lag.
Menopause Brain Fog
Wondering if it's just hormones or something more serious.
THE COGSPAN FRAMEWORK
Assess. Optimize.
Prove it worked.
1
STEP ONE
Find the Nothings
Over 300 lifestyle, biological, environmental, functional, strength and mobility data points are collected and meticulously pinned to one of 10 Living Domains. It is the precise mapping of every single data point that reveals the hidden pattern of aging — the one conventional medicine is not designed to see.
II
STEP TWO
Score & Identify Your Pattern
Our mathematical model generates Domain scores, weighing every critical data point according to medical literature, then normalizing them. We calculate your biological age and identify your top two aging accelerators with confidence.
III
STEP THREE
Your CogSpan Blueprint
This is the magic sauce. Your CogSpan Blueprint provides detailed, expert-guided instructions on exactly how to improve your worst Domain score over 6 months —you will see that a ripple effect forms and your Domain scores will improve in multiple areas. After 6 months, we repeat the entire assessment. The proof will be in the numbers.
THE 10 LIVING DOMAINS
Brain Performance & Cognitive Aging
Inflammation & Immune Aging
Sleep, Circadian Rhythm & Recovery
Cardiovascular & Vascular Aging
Lifestyle, Purpose & Cognitive Reserve
Metabolic & Glycemic Stability
Mitochondrial Energy & Oxidative Stress
Hormonal & Neuroendocrine Balance
Physical Function, Strength & Mobility
Risk Behaviors, Environment & Health Engagement
300+
Data points per assessment
Every point strategically mapped to a Living Domain — scored, ranked, and assigned targeted interventions.
This is not a standard blood panel with a follow-up appointment. This is a complete biological audit of every system that feeds — or fails — your brain.
THE SCIENCE GOES DEEP
We don't guess. We measure.
Before any intervention is recommended, we conduct one of the most comprehensive intake assessments available in integrative medicine — mapping your brain, your biology, your environment, and your body from every clinically meaningful angle.
BRAIN FUNCTION
Cognitive Performance Testing We establish your personal baseline across processing speed, working memory, attention, and executive function using validated digital cognitive assessment technology. Every intervention in your protocol is measured against this number — not a feeling.
INFLAMMATION, HORMONES & NUTRITION
Neuroinflammation We quantify systemic inflammation — one of the most modifiable drivers of brain aging and a direct contributor to the synaptic dysfunction underlying brain fog.
​
Thyroid Function We assess thyroid health with the precision it deserves — subclinical thyroid dysfunction is dramatically underdiagnosed in perimenopausal women and is a direct, reversible cause of cognitive slowing and fatigue.
Iron & Cellular Energy We measure iron storage, a marker of cellular energy production and neurological function that is frequently low in women and rarely evaluated in the context of cognitive complaints.
Neurological Foundations We assess two nutrients foundational to myelin integrity, mood regulation, and memory formation — deficiency in either is common, consequential, and correctable.
Broad Metabolic Screen A comprehensive urinary screen provides additional signals across metabolic, inflammatory, and kidney-related pathways that targeted blood testing alone may not capture.
PHYSICAL FUNCTION
Mobility & Strength Assessment Grip strength, balance, gait quality, and functional mobility are each independent predictors of cognitive trajectory and dementia risk. Physical resilience and brain health share overlapping neurobiology — deficits identified here are among the most responsive targets for early intervention.
METABOLIC HEALTH
Blood Sugar & Insulin Regulation We assess how well your body regulates blood sugar and insulin — because insulin resistance is one of the most powerful and most overlooked drivers of cognitive decline, now referred to by some researchers as "Type 3 Diabetes."
​
Cardiovascular & Alzheimer's Risk We go far beyond standard cholesterol, measuring true cardiovascular particle burden and genotyping for the strongest known genetic risk factor for Alzheimer's disease — information that fundamentally changes how aggressively your neuroprotective protocol needs to be calibrated.
​
Methylation & Stroke Risk We test for an independent risk factor for stroke, cognitive decline, and neurodegeneration that is almost entirely correctable with targeted nutritional therapy — and almost never ordered at a standard checkup.
​
Kidney & Vascular Health Targeted markers give us an early window into vascular and kidney health, both of which directly affect brain blood flow and cognitive resilience.
Organ Function Baseline A broad metabolic and blood cell assessment evaluates liver and kidney function, electrolyte balance, and immune status — the biological foundation everything else is built on.
ORAL MICROBIOME
Oral Microbiome Assessment Specific oral pathogens — including bacteria that have been detected in the brains of Alzheimer's patients — are associated with systemic neuroinflammation and amyloid accumulation. We assess your oral microbiome to identify pathogenic bacterial overgrowth that may be silently driving cognitive symptoms from the inside of your mouth.
ENVIRONMENTAL TOXIN BURDEN
​
Mold & Mycotoxin Exposure We test for a panel of clinically significant mycotoxins — directly linked to progressive brain fog, memory loss, and neuroinflammation — that most physicians never consider. Many patients have no idea their home or workplace is the source of their cognitive symptoms.
​
Environmental Chemical Exposure We screen for a broad range of neurotoxic chemical exposures, with particular attention to compounds that actively interfere with estrogen signaling in the brain — compounding the hormonal depletion of menopause at the cellular level.
​
Mitochondrial & Detox Function A metabolic profiling panel reveals how your body's detoxification pathways, mitochondrial energy production, and neurotransmitter metabolism are performing under toxic load — showing us not just what toxins are present, but what they are doing to your biology.
​
CARDIOVASCULAR & AUTONOMIC FUNCTION
Orthostatic Heart Rate Response We measure your heart rate at rest and one minute after standing — a simple but powerful test of how well your autonomic nervous system delivers blood to your brain. A dysregulated response here is a direct, measurable, and frequently missed cause of cognitive impairment.
Resting Vitals Blood pressure, heart rate, oxygen saturation, respiratory rate, and temperature establish your cardiovascular baseline and frequently reveal patterns that more sophisticated testing alone would miss.

61
COGSPAN SCORE
Initial assessment
AN EXAMPLE
His labs were normal.
His brain wasn't.
Mark, 52, was a senior executive who'd been hitting a hard wall every day at 1pm — a cognitive crash that didn't used to happen. By evening he had nothing left. His doctor ran every standard lab. All normal. He assumed it was stress, maybe age, and kept pushing through.
His CogSpan assessment told a different story. Score: 61. Two primary accelerators identified — mitochondrial dysfunction and toxic burden from environmental exposure. Neither showed up on a single routine lab. Six months into his protocol, his score is 74. He finishes his days sharp.
300+
Data points assessed
10
Living Domains evaluated
6 mos
Protocol · Score proven
CUSTOMIZE YOUR BLUEPRINT
One program. Built to watch over your brain so you can build your legacy.
Including multiple enhancements to tailor it--your way.
FLAGSHIP
PATENT-PENDING
CogSpan Immersive
6-month immersive program for: professionals over age 40 with family history of dementia, concerns about brain health or signs of cognitive slipping.
INCLUDED ADVANCED BIOMARKERS
200+ advanced biomarkers
INSURANCE-BILLED BIOMARKERS
100+ additional biomarkers billed to insurance, including Neuroinflammation + dementia risk
COGNITIVE TESTING
BrainCheck cognitive testing on enrollment, mid-program and at end of program
ORAL MICROBIOME
Oral microbiome panel — on enrollment and mid-program
ASSESSMENT
Full baseline assessment with 100+ item CogSpan Questionnaire, mobility assessments, labs billed to insurance plus review by a physician--not AI.
BRAIN MRI
Brain MRI if indicated, with estimates of brain weight, billed to insurance
SUPPLEMENTS AND PRESCRIPTIONS
Three Domain-targeted Supplements Included. Prescriptions, if needed, billed to insurance
DIET GUIDANCE
My Living Eats diet app — diet prescribed & loaded by CogSpan Council (six-month subscription)
My Living Eats diet app — diet prescribed & loaded by CogSpan Council (6-month subscription)
ADD-ON
MORE SERVICES
Enhancements to Build your CogSpan Immersive Program Your Way
COGSPAN VIRTUAL COUNCIL PACK
ADD-ON: VIP Coordinator, 12 Sessions of life-coaching in Menopause, Nutrition and Fitness, CogSpan Council (physician, each of your coaches and your VIP Coordinator) reviews every detail of your case every few months and tweaks your Blueprint as you move through your Program, BrainCheck Cognitive Testing increases to monthly.
COGSPAN VIRTUAL NUTRITION PACK
ADD-ON: Three Sessions with Registered Dietician, six sessions of Menopause & Nutrition Life Coaching. Continuous Glucose Monitor for 14 days
COGSPAN VIRTUAL SLEEP PACK
ADD-ON: WatchPAT sleep study, meditation training sessions x 2, hormone optimization
COGSPAN CORE =
ALL OF THE ABOVE
COGSPAN COUNCIL PACK + NUTRITION PACK + SLEEP PACK
COGSPAN PASADENA LOCATION ONLY
FITNESS PACK
ADD-ON: Three sessions with Fitness Life Coach, two Personal Training sessions, 48 (twice weekly) small group supervised Strength & Mobililty classes
COGSPAN PASADENA LOCATION ONLY:
REGENERATIVE MEDICINE PACK
ADD-ON: Stem cell infusions or injections, occular, injection or infusions of exosomes, and peptides as customized based on your needs.
COGSPAN CORE ELITE=
ALL OF THE ABOVE
COGSPAN COUNCIL PACK + NUTRITION PACK + SLEEP PACK + FITNESS PACK + ELITE REGEN PACK--IN OUR PASADENA FACILITY ONLY
HSA/FSA eligible · Financing available · Letter of Medical Necessity provided · Insurance billing for labs and medications where applicable


THE COGSPAN COUNCIL
One integrated system.
At the core of every CogSpan program is your dedicated Council — a team that meets regularly to review your progress, refine your Roadmap, and ensure your care is continuously aligned and optimized.
CLINICAL LEAD
Physician MD
Protocol director and medical oversight. Alexis Anvekar MD, ABIHM leads the clinical framework.
NUTRITION
Registered Dietitian
Metabolic and microbiome-focused nutrition strategy. Prescribes your personalized diet plan.
MOVEMENT
Fitness Coach
Neuroplasticity movement protocol. Evidence-based training designed around longevity outcomes.
ACCOUNTABILITY
Nutrition Coach
Daily coaching and accountability. Ensures the protocol is executed and adjusted in real time.
Your VIP Coordinator creates a seamless experience
Unlike standard care — where a single provider has limited time, data is siloed, labs are ordered then forgotten, and there's no longitudinal tracking — the CogSpan Council reviews your data together. Your VIP Coordinator ensures every piece of your care is connected, coordinated, and continuously optimized.
180
DAY
PROMISE
If you don't score 10% higher at month 6, we extend your program — free.
We're so confident in the depth of this protocol that we back it with our 180-Day Progress Guarantee.
If your CogSpan Objective Engine Score hasn't improved by at least 10% at month 6 and you've followed the protocol as prescribed, we will expand your program until it does.
THE REAL PROMISE
We are here to watch over your brain
so you can build and enjoy your legacy.
Energy for Your Family
Finishing a demanding day and still walking through the door with something left for the people who matter most.
Physical Presence
Picking up your grandchild without thinking twice. Not falling. Moving through life with strength and confidence.
Still Building at 70, Still Sharp at 90
Creating, leading, and contributing at full capacity — not just surviving the decades ahead.
Legacy Fully Experienced
Walking down the aisle at your great-granddaughter's wedding — present, clear, and recognizing every beautiful detail.

"The most frightening future isn't dying. It's being alive — but not fully present."
ALEXIS ANVEKAR MD, THE LIVING METHOD

MEET THE FOUNDER
Alexis Anvekar
MD, ABIHM
FOUNDER · THE LIVING METHOD™
Throughout my career, I kept seeing the same gap: the system is designed to treat disease after it appears — not to measure and modify the factors that shape long-term cognitive health before it's too late.
That realization led me to build something different. A more structured, proactive approach that integrates clinical medicine, advanced diagnostics, and longitudinal measurement into a repeatable, personalized framework.
My work focuses on helping individuals understand their cognitive trajectory, reduce hidden aging risks, and improve brain performance over time — with measurable, data-driven results, not guesswork.
CREDENTIALS
MD, ABIHM — Board Certified in Integrative & Holistic Medicine · Board Certified in Internal Medicine, National Board of Physicians & Surgeons
SPECIALTY
Cognitive longevity, precision diagnostics, brain performance
INNOVATION
Creator of the patent-pending Longevity Intelligence System
LOCATION
The Living Method · Pasadena, California
APPLY FOR ENROLLMENT
Cohorts open quarterly. Enrollment is intentionally limited to maintain clinical quality.
100% personalized. 10 Domains evaluated. 6-month protocol. Your brain built everything you have.
HSA/FSA eligible
Financing available
Insurance billing where applicable
Letter of Medical Necessity provided


